Transient cardiac expression of the tinman-family homeobox gene, XNkx2-10
نویسندگان
چکیده
منابع مشابه
Transient cardiac expression of the tinman-family homeobox gene, XNkx2-10
In Drosophila, the tinman homeobox gene is absolutely required for heart development. In the vertebrates, a small family of tinman-related genes, the cardiac NK-2 genes, appear to play a similar role in the formation of the vertebrate heart. However, targeted gene ablation of one of these genes, Nkx2-5, results in defects in only the late stages of cardiac development suggesting the presence of...
متن کاملCardiac enhancer activity of the homeobox gene tinman depends on CREB consensus binding sites in Drosophila.
The Drosophila homeobox gene tinman plays a critical role in subdividing the early mesoderm. In particular, tinman is absolutely required for formation of the heart and visceral mesoderm. tinman expression is initiated throughout the mesoderm of the trunk region under the control of the bHLH transcription factor encoded by the twist gene, a determinant of all mesoderm. Later, tinman expression ...
متن کاملVertebrate tinman homologues XNkx2-3 and XNkx2-5 are required for heart formation in a functionally redundant manner.
Tinman is a Drosophila homeodomain protein that is required for formation of both visceral and cardiac mesoderm, including formation of the dorsal vessel, a heart-like organ. Although several vertebrate tinman homologues have been characterized, their requirement in earliest stages of heart formation has been an open question, perhaps complicated by potential functional redundancy of tinman hom...
متن کاملExpression of Recombinant Factor IX Using the Transient Gene Expression Technique
Background: Pilot and large-scale production of recombinant proteins requires the presence of stable clones capable of producing large quantities of recombinant proteins. Not only the process of selecting stable clones is time consuming, but also the continuous culturing of clones in large-scale production may cause loss of incoming plasmid and recombinant genes. Thus, considering the advanceme...
متن کاملThe murine homeobox gene Csx/Nkx2.5 is an evolutionarily highly conserved gene related to the Drosophila tinman
The molecular mechanisms which guide development of the heart, in vertebrates and many other species, have been the subject of intense investigation in recent years (Fishman and Chien, 1997; Olson and Srivastava, 1996). These studies have suggested common molecular pathways which are evolutionarily conserved from simpler species such as Drosophila to higher species including mammals (Bodmer and...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2000
ISSN: 0925-4773
DOI: 10.1016/s0925-4773(99)00291-9